Antioxidant BHT 264
CAS:128-37-0
Purity:99%
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Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart
![tert-butyl 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate](/upload/2025/1/4ceac431-75ec-4abc-9ad4-a2530137efc3.png)
tert-butyl 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate
telmisatran
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
In
tetrahydrofuran;
at 100 ℃;
Reagent/catalyst;
Solvent;
|
93% |
|
With
trifluoroacetic acid;
In
N,N-dimethyl-formamide;
for 4h;
|
70% |
|
With
trifluoroacetic acid;
In
N-methyl-acetamide;
|
63.9% |
|
With
trifluoroacetic acid;
In
dichloromethane;
for 24h;
Yield given;
Ambient temperature;
|
![tert-butyl-4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate hydrochloride](/upload/2025/1/16ce8e12-ba81-4448-9530-0a5fe0f3c4c0.png)
tert-butyl-4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate hydrochloride
telmisatran
| Conditions | Yield |
|---|---|
|
tert-butyl-4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate hydrochloride;
With
acetic acid;
In
water;
Heating / reflux;
With
sodium hydroxide;
In
water;
at 80 - 90 ℃;
|
93.3% |
|
With
sodium hydroxide; water;
In
water; acetic acid;
at 80 - 90 ℃;
Heating / reflux;
|
93.3% |
The CAS number of Telmisartan is 144701-48-4.
More information of Telmisartan 144701-48-4 are:
|
CAS Number |
144701-48-4 |
|
Density |
1.24 g/cm3 |
|
Melting Point |
261-263 °C |
|
Boiling Point |
771.9 °C at 760 mmHg |
|
Flash Point |
420.6 °C |
|
Vapor Pressure |
0mmHg at 25°C |
|
Refractive Index |
1.624 |
|
HS CODE |
2933995300 |
|
PSA |
72.94000 |
|
LogP |
7.26440 |
|
Pka |
3.86±0.36(Predicted) |
Synonyms for Telmisartan 144701-48-4:(1,1-Biphenyl)-2-carboxylic acid, 4-((1,4-dimethyl-2-propyl(2,6-bi-1H-benzimidazol)-1-yl)methyl)-;Micardis;4-((4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid;Timetazidine;4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]- [1,1'-biphenyl]-2-carboxylic acid;
The chemical formula of Telmisartan is C33H30N4O2 which containing 33 Carbon atoms,30 Hydrogen atoms,4 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of Telmisartan is 514.627.
Telmisartan was launched in the US for the treatment of hypertension. It can be prepared in eight steps starting with methyl 4-amino-3-methyl benzoate; the first and second cyclization into a benzimidazole ring occur at steps 4 and 6 respectively. Telmisartan blocks the action of angiotensin II (Ang II), the primary effector molecule of the renin-angiotensin-aldosterone system (RAAS). It is the sixth of this class of 《sartans》 to be marketed after the lead compound Losartan. Its long lasting effect (24h half-life) could be the main difference with other angiotensin II antagonists. Unlike several other agents in this category, its activity does not depend upon transformation into an active metabolite, the 1-O-acylglucuronide being the principal metabolite found in humans. Telmisartan is a potent competitive antagonist of AT1 receptors that mediate most of the important effects of angiotensin II while lacking affinity for the AT2 subtypes or other receptors involved in cardiovascular regulation. In several clinical studies, Telmisartan, at a once daily dosage, produced effective and sustained blood-pressure lowering effects with a low incidence of side effects (particularly treatment-related cough associated with ACE inhibitors in elderly patients).
InChI:InChI=1/C33H30N4O2/c1-7-12-33-39-34-24(2)21-27(35-38-30-15-10-11-16-31(30)40(35)6)22-32(34)41(33)23-25-17-19-26(20-18-25)28-13-8-9-14-29(28)36(42)43-37(3,4)5/h8-11,13-22H,7,12,23H2,1-6H3
Relevant articles related to Telmisartan:
|
Article |
Source |
|
An improved synthesis of telmisartan: Via the copper-catalyzed cyclization of o -haloarylamidines |
Li, Rui,Shen, Jingshan,Sun, Changliang,Zhang, Junchi,Zhu, Fuqiang , p. 13717 - 13721 (2020) |
|
Preparation method of telmisartan |
- Paragraph 0027; 0038-0040; 0051-0053; 0064-0065, (2021/08/28) |
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