What is the 1-Naphthyl acetonitrile?

1-Naphthyl acetonitrile is White crystalline powder, while it's Molecular Formula is C12H9N. White crystalline powder 2-(Naphthalen-1-yl)acetonitrile is useful for the preparation of tert-Bu benzoates.

What is the CAS number for 1-Naphthyl acetonitrile?

The CAS number of 1-Naphthyl acetonitrile is 132-75-2.

What is 1-Naphthyl acetonitrile (132-75-2) used for?

1-Naphthyl acetonitrile, also known as 2-(Naphthalen-1-yl)acetonitrile, is an organic compound that serves as an important intermediate in chemical synthesis. It is a white to yellow solid or melt, which is insoluble in water.InChI:InChI=1/C12H9N/c13-9-8-11-6-3-5-10-4-1-2-7-12(10)11/h1-7H,8H2

What is the 1-Naphthyl acetonitrile?

1-Naphthyl acetonitrile is White crystalline powder, while it's Molecular Formula is C12H9N. White crystalline powder 2-(Naphthalen-1-yl)acetonitrile is useful for the preparation of tert-Bu benzoates.

What is the CAS number for 1-Naphthyl acetonitrile?

The CAS number of 1-Naphthyl acetonitrile is 132-75-2.

What is 1-Naphthyl acetonitrile (132-75-2) used for?

1-Naphthyl acetonitrile, also known as 2-(Naphthalen-1-yl)acetonitrile, is an organic compound that serves as an important intermediate in chemical synthesis. It is a white to yellow solid or melt, which is insoluble in water.InChI:InChI=1/C12H9N/c13-9-8-11-6-3-5-10-4-1-2-7-12(10)11/h1-7H,8H2

1-Naphthylacetonitrile

CAS：132-75-2
MF：C₁₂H₉N
Purity：99%
Molecular Weight：167.21

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Product Details

CAS： 132-75-2

MF： C₁₂H₉N

Appearance： White crystalline powder

Export Top Purity 1-Naphthylacetonitrile 132-75-2 In Stock

Molecular Formula:C12H9N
Molecular Weight:167.21
Appearance/Colour:White crystalline powder
Vapor Pressure:0.000255mmHg at 25°C
Melting Point:33-35 °C(lit.)
Refractive Index:n20/D 1.6192(lit.)
Boiling Point:323.9 °C at 760 mmHg
Flash Point:180.3 °C
PSA：23.79000
Density:1.116 g/cm³
LogP:2.90588

1-Naphthyl acetonitrile(Cas 132-75-2) Usage

Preparation	Synthesis of 1-naphthylacetonitrile: 695g of 1-chloromethyl naphthalene, 1500ml of methanol and 475ml of water, 350g of sodium cyanide mixture boiling reflux, stirring the reaction for 2h. 1300ml of methanol was evaporated, cooled, and the reactants were washed with water to neutral to obtain 670-680g of 1-naphthylacetonitrile.
Synthesis Reference(s)	Chemical and Pharmaceutical Bulletin, 39, p. 3030, 1991 DOI: 10.1248/cpb.39.3030
Application	1-Naphthylacetonitrile is an organic synthesis intermediate. It is used in the synthesis of 1-naphthylacetate.

InChI:InChI=1/C12H9N/c13-9-8-11-6-3-5-10-4-1-2-7-12(10)11/h1-7H,8H2

132-75-2 Relevant articles

-

King,Henshall

, p. 417 (1945)

Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes

Liu, Richard Y.,Bae, Minwoo,Buchwald, Stephen L.

, p. 1627 - 1631 (2018)

Metal-catalyzed silylative dehydration o...

Synthesis, characterisation, optical properties and theoretical calculations of a new fluorescent heterocyclic system: 3H-benzo[a]pyrazolo[3,4-j]acridine

Alipoor, Hamideh,Pordel, Mehdi,Morsali, Ali

, p. 371 - 375 (2017)

Four new fluorescent dyes derived from t...

Straightforward conversion of alcohols into nitriles

Tarrade-Matha, Aurelie,Pillon, Florence,Doris, Eric

, p. 1646 - 1649 (2010)

The reaction of various alcohols with cy...

Mild and reversible dehydration of primary amides with PdCl2 in aqueous acetonitrile

Maffioli, Sonia I.,Marzorati, Ettore,Marazzi, Alessandra

, p. 5237 - 5239 (2005)

(Chemical Equation Presented) A new, mil...

-

Rossi et al.

, p. 3371 (1976)

-

Briggs,Wilson

, p. 500 (1941)

Facile dehydration of primary amides to nitriles catalyzed by lead salts: The anionic ligand matters

Ruan, Shixiang,Ruan, Jiancheng,Chen, Xinzhi,Zhou, Shaodong

, (2020/12/09)

The synthesis of nitrile under mild cond...

Method for dehydrating primary amide into nitriles under catalysis of cobalt

-

Paragraph 0078-0080, (2021/06/21)

The invention provides a method for dehy...

Preparation method of naphthalene ring C marked α .

-

, (2021/10/05)

The invention discloses C labeled α - na...

Assembly of α-(Hetero)aryl Nitriles via Copper-Catalyzed Coupling Reactions with (Hetero)aryl Chlorides and Bromides

Chen, Ying,Xu, Lanting,Jiang, Yongwen,Ma, Dawei

supporting information, p. 7082 - 7086 (2021/02/26)

α-(Hetero)aryl nitriles are important st...

132-75-2 Process route

: 86-86-2
1-Naphthylacetamide

: 132-75-2
naphthalen-1-ylacetonitrile

Conditions

Conditions	Yield
With trichloromethyl chloroformate; In various solvent(s); 0-5 deg C then heated to 60 deg C, 5 min;	96%
With (dimethoxy)methylsilane; copper diacetate; 1,2-bis-(dicyclohexylphosphino)ethane; In tetrahydrofuran; at 20 ℃; for 12h; Sealed tube;	96%
With phosgene; In tetrahydrofuran; toluene; at 25 ℃; for 4h; Inert atmosphere;	91%
With lead acetate; In dichloromethane; for 12h; Reflux;	90%
With 1,3,5-trichloro-2,4,6-triazine; In N,N-dimethyl-formamide; for 14h; Ambient temperature;	85%
With 1,3,5-trichloro-2,4,6-triazine; In N,N-dimethyl-formamide; for 14h; Product distribution; Ambient temperature; also in dioxan, other temperature, other time;	85%
With C₂₀H₂₅Cl₂CoN₃; sodium triethylborohydride; In toluene; at 60 ℃; for 6h; Inert atmosphere;	85%
With ammonium sulfamate salt;
palladium dichloride; In water; acetonitrile; at 20 ℃; for 16h;	80 % Chromat.

: 91-20-3,71998-51-1,72931-45-4
naphthalene

: 107-14-2
chloroacetonitrile

: 132-75-2
naphthalen-1-ylacetonitrile