Levomethadyl acetate hydrochloride

  • CAS:43033-72-3
  • MF:C23H31 N O2 . Cl H
  • Purity:99%
  • Molecular Weight:389.966
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Product Details

  • CAS: 43033-72-3
  • MF: C23H31 N O2 . Cl H
  • Top Quality Chinese Manufacturer supply 43033-72-3 Levomethadyl acetate hydrochloride

    • Molecular Formula:C23H31 N O2 . Cl H
    • Molecular Weight:389.966
    • Vapor Pressure:1.68E-08mmHg at 25°C 
    • Melting Point:215° 
    • Boiling Point:456°Cat760mmHg 
    • Flash Point:130°C 
    • PSA:29.54000 
    • Density:g/cm3 
    • LogP:5.45660 

    Levomethadyl acetate hydrochloride(Cas 43033-72-3) Usage

    Brand name

    Orlaam (Roxane).

    InChI:InChI=1/C23H31NO2.ClH/c1-6-22(26-19(3)25)23(17-18(2)24(4)5,20-13-9-7-10-14-20)21-15-11-8-12-16-21;/h7-16,18,22H,6,17H2,1-5H3;1H/t18-,22-;/m0./s1

    43033-72-3 Relevant articles

    Synthesis of optically active methadones, LAAM and bufuralol by lipase-catalysed acylations

    Hull, Jonathan D.,Scheinmann, Feodor,Turner, Nicholas J.

    , p. 567 - 576 (2007/10/03)

    (R)- and (S)-Methadones and levo-α-acety...

    43033-72-3 Process route

    (3S,6S)-Methadol
    14019-10-4

    (3S,6S)-Methadol

    acetyl chloride
    75-36-5

    acetyl chloride

    levomethadyl acetate hydrochloride
    43033-72-3

    levomethadyl acetate hydrochloride

    Conditions
    Conditions Yield
    In ethyl acetate; for 2h; Heating;
    84%
    Diphenylacetonitrile
    86-29-3

    Diphenylacetonitrile

    levomethadyl acetate hydrochloride
    43033-72-3

    levomethadyl acetate hydrochloride

    Conditions
    Conditions Yield
    Multi-step reaction with 4 steps
    1: 33 percent / aq. NaOH; dibenzo-18-crown-6 / dimethylsulfoxide / 1 h / 45 - 50 °C
    2: 53 percent / toluene / 135 - 140 °C / 3 Torr
    3: 100 percent / CeCl3*7H2O; NaBH4 / ethanol / 3 h / 20 °C
    4: 84 percent / ethyl acetate / 2 h / Heating
    With sodium hydroxide; sodium tetrahydroborate; dibenzo-18-crown-6; cerium(III) chloride; In ethanol; dimethyl sulfoxide; ethyl acetate; toluene; 2: Grignard reaction;

    43033-72-3 Upstream products

    • 14019-10-4
      14019-10-4

      (3S,6S)-Methadol

    • 75-36-5
      75-36-5

      acetyl chloride

    • 86-29-3
      86-29-3

      Diphenylacetonitrile

    • 7576-08-1
      7576-08-1

      (S)-(+)-2,2-diphenyl-4-dimethylaminopentanenitrile

    Antioxidant BHT 264

    CAS:128-37-0

    Purity:99%

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