Antioxidant BHT 264
CAS:128-37-0
Purity:99%
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Product Details
InChI:InChI=1/C15H15N/c1-2-7-13(8-3-1)15-14-9-5-4-6-12(14)10-11-16-15/h1-9,15-16H,10-11H2/t15-/m0/s1
We report herein a simple alternative me...
A highly stereoselective synthesis of 1-...
The successful development of a catalyti...
Artificial metalloenzymes (ArMs) based o...
Tetrahydroisoquinolines (THIQs) with a C...
S(-)1-Phenyl-1,2,3,4-tetrahydro isoquino...
Ferritin, a naturally occuring iron-stor...
The title compounds (S)-(+)-8 and (R)-(-...
The transition-metal-catalyzed C?N cross...
The use of arene/Ru/TsDPEN catalysts bea...
The invention relates to a (S)1-phenyl-1...
The invention relates to a synthetic met...
1-phenyl-3,4-dihydroisoquinoline
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
| Conditions | Yield |
|---|---|
|
With
sodium tetrahydroborate;
In
ethanol;
at 20 ℃;
for 60h;
|
|
|
With
hydrogen;
bis(1,5-cyclooctadiene)diiridium(I) dichloride; (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine);
In
tetrahydrofuran; 1,1-dichloroethane;
at 20 - 50 ℃;
under 22502.3 Torr;
Product distribution / selectivity;
Inert atmosphere;
|
50 % ee |
|
With
1,1'-bis-(diphenylphosphino)ferrocene; bis(1,5-cyclooctadiene)diiridium(I) dichloride; hydrogen; iodine;
In
dichloromethane;
at 20 ℃;
for 24h;
under 38002.6 Torr;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
Autoclave;
|
|
|
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R)-3,5-diMe-Synphos; hydrogen;
In
1,4-dioxane;
at 40 ℃;
for 18h;
under 22502.3 Torr;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
|
|
|
With
formic acid; [RuCl(η6-benzene)(1R,2R)-N-(naphthalene-1-sulfonyl)-1,2-diphenylethylenediamine]; triethylamine;
In
acetonitrile;
at 30 ℃;
Reagent/catalyst;
|
39 % ee |
|
With
(2S,3R)-2-amino-3-hydroxybutanamide; streptavidin biotin-wild type; C42H64Cl4Ir2N6O4S2;
In
dimethyl sulfoxide;
at 30 - 50 ℃;
for 18h;
pH=7.8;
Reagent/catalyst;
Overall yield = 96 %; enantioselective reaction;
|
63 % ee |
|
With
C42H64Cl4Ir2N6O4S2; D-Phenylalaninamide;
In
dimethyl sulfoxide;
at 30 - 50 ℃;
for 18.25h;
pH=7.8;
Reagent/catalyst;
Overall yield = 99 %; enantioselective reaction;
|
16 % ee |
|
With
[N-[(1S,2S)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2,3,4,5,6-η)-1,3,5-trimethylbenzene]ruthenium; formic acid; triethylamine;
In
acetonitrile;
for 1.16667h;
Optical yield = 2 %ee;
|
|
|
With
[N-[(1S,2S)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2,3,4,5,6-η)-1,3,5-trimethylbenzene]ruthenium; formic acid; triethylamine;
In
isopropyl alcohol;
at 30 ℃;
for 16h;
Overall yield = 90 %; enantioselective reaction;
Inert atmosphere;
|
29 % ee |
|
With
N-[(1S,2S)-1,2-diphenyl-2-(3-phenylpropylamino)ethyl]-4-methylbenzene sulfonamide ammonium chloride ruthenium; hydrogen; trifluoroacetic acid;
In
methanol;
at 40 ℃;
for 6h;
under 11251.1 Torr;
Reagent/catalyst;
Autoclave;
Sealed tube;
|
11 % ee |
|
With
hydrogen;
In
tetrahydrofuran; toluene;
at 30 ℃;
for 17h;
under 45603.1 Torr;
Reagent/catalyst;
Solvent;
enantioselective reaction;
Autoclave;
|
24 % ee |
|
With
(pentamethylcyclopentadienyl)IrCl[κ2(N,N')-(S,S)-p-toluenesulfonylNCHPhCHPhNH2]; hydrogen; trifluoroacetic acid;
In
methanol;
for 6h;
under 11251.1 Torr;
stereoselective reaction;
|
71 % ee |
|
With
D-glucose; BmGDH; imine reductase from Stackebrandtia nassauensis; NADP;
In
aq. phosphate buffer; dimethyl sulfoxide;
at 30 ℃;
for 12h;
pH=7;
Overall yield = 81 %; Overall yield = 170 mg; enantioselective reaction;
Enzymatic reaction;
|
51 % ee |
|
With
formic acid; (1,2,3,4,5-pentamethylcyclopentadienyl)Ir[κ2(N,N')-CH3C6H4SO2NCHPhCHPhNH]; phosphoric acid; triethylamine;
In
isopropyl alcohol;
at 30 ℃;
for 3h;
Reagent/catalyst;
Solvent;
Overall yield = 90 %; Overall yield = 28.4 mg; enantioselective reaction;
Catalytic behavior;
Inert atmosphere;
Schlenk technique;
|
86 % ee |
|
With
D-Glucose; NADPH;
at 30 ℃;
for 24h;
enantioselective reaction;
Enzymatic reaction;
|
30 % ee |
|
Multi-step reaction with 2 steps
1: borane-ammonia complex
2: LG-I-D11 / Resolution of racemate; Enzymatic reaction
With
borane-ammonia complex; LG-I-D11;
|
|
|
With
N-Bromosuccinimide; bis(1,5-cyclooctadiene)diiridium(I) dichloride; hydrogen; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl;
In
1,2-dichloro-ethane;
at 0 ℃;
for 36h;
under 25858.1 Torr;
Reagent/catalyst;
Solvent;
Overall yield = 92 %; Overall yield = 57 mg; enantioselective reaction;
Catalytic behavior;
Glovebox;
|
86 % ee |
|
With
Cp*Ir(biot-p-L)Cl; streptavidin S112A-N118P-K121A mutant;
In
aq. buffer;
at 37 ℃;
for 4h;
enantioselective reaction;
Catalytic behavior;
Sealed tube;
Enzymatic reaction;
|
85 % ee |
|
With
Cp*Ir(biot-p-L)Cl; streptavidin S112A-N118P-K121A mutant;
In
aq. buffer;
at 37 ℃;
for 4h;
Reagent/catalyst;
enantioselective reaction;
Catalytic behavior;
Sealed tube;
Enzymatic reaction;
|
86 % ee |
|
With
N-Bromosuccinimide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; sodium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,2-dichloro-ethane;
at 30 ℃;
for 24h;
under 25858.1 Torr;
enantioselective reaction;
Glovebox;
|
88 % ee |
|
With
N-Bromosuccinimide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
1,2-dichloro-ethane;
at 0 ℃;
for 36h;
under 25858.1 Torr;
Temperature;
Reagent/catalyst;
Solvent;
Overall yield = 92 %; enantioselective reaction;
Glovebox;
|
82 % ee |
|
With
Cp*Ir(biot-p-L)Cl; streptavidin S112A-N118P-K121A mutant; sodium formate;
In
aq. buffer;
at 37 ℃;
for 48h;
pH=6;
Reagent/catalyst;
Temperature;
enantioselective reaction;
Catalytic behavior;
|
86 % ee |
|
With
Cp*Ir(biot-p-L)Cl; streptavidin S112R-N118P-K121A-S122M-L124Y mutant; sodium formate;
In
aq. buffer;
at 37 ℃;
for 48h;
pH=6;
Reagent/catalyst;
Temperature;
enantioselective reaction;
Catalytic behavior;
|
78 % ee |
|
With
sodium formate; sodium hydroxide;
In
aq. buffer;
at 37 ℃;
for 48h;
pH=7;
Reagent/catalyst;
Catalytic behavior;
|
64 % ee |
|
With
recombinant FPD-chimera streptavidin Sav-FPD; [Cp*Ir(biot-p-L)Cl];
In
dimethyl sulfoxide;
at 25 ℃;
for 16h;
pH=7;
Reagent/catalyst;
enantioselective reaction;
Catalytic behavior;
Enzymatic reaction;
|
60 % ee |
|
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; C42H46FeP2; hydrogen; trifluoroacetic acid;
In
tetrahydrofuran;
at 30 ℃;
for 12h;
under 38002.6 Torr;
Reagent/catalyst;
Temperature;
Solvent;
enantioselective reaction;
Catalytic behavior;
Autoclave;
Schlenk technique;
|
85 % ee |
|
With
Cp*Ir(biot-p-L)Cl; MASMTGGQQMGRDQAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTAGTTEANAWASTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQGSGGGNGGGNGGGNGGGNIDGRGGGNASMTGGQQMGRDQAGITGTWYNQLGSTFIVTAGADGALTGTYVTARGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTAGTTEANAWASTLVGCDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ;
In
dimethyl sulfoxide;
at 25 ℃;
for 24h;
pH=7;
Reagent/catalyst;
Sealed tube;
|
54 % ee |
|
With
Cp*Ir(biot-p-L)Cl; MASMTGGQQMGRDQAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTAGTTEANAWASTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQGSGGGNGGGNGGGNGGGNIDGRGGGNASMTGGQQMGRDQAGITGTWYNQLGSTFIVTAGADGALTGTYVTARGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTAGTTEANAWKSTLVGCDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ;
In
dimethyl sulfoxide;
at 25 ℃;
for 24h;
pH=7;
Reagent/catalyst;
Sealed tube;
|
17 % ee |
|
With
1-dodecyl-3-methylimidazolium bis(2,4,4-trimethylpentyl)phosphinate; C31H33ClN2O8RuS3(2-)*2Na(1+); sodium formate;
In
n-heptane; water;
at 60 ℃;
Overall yield = 10 percentChromat.; enantioselective reaction;
Inert atmosphere;
|
26 % ee |
|
With
formic acid; C33H37ClN2O4RuS; triethylamine;
In
dichloromethane;
at 20 ℃;
for 96h;
Reagent/catalyst;
enantioselective reaction;
Inert atmosphere;
Schlenk technique;
|
49 % ee |
4-nitrophenyl-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(R)-(-)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
| Conditions | Yield |
|---|---|
|
4-nitrophenyl-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate;
With
sodium hydroxide;
In
ethanol;
at 75 - 80 ℃;
With
water;
Cooling;
|
(1S,1'R)-2-(2-hydroxy-1-phenylethyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(S)-(-)-benzyl 1-phenyl-1,2-dihydroisoquinoline-2-carboxylate
(S)-(-)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(1S,5R)-5,8,8-trimethyl-1-[(1S)-1-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ylcarbonyl]-3-oxabicyclo[3.2.1]octan-2-one
5-<2-(1-phenyl)tetrahydroisoquinolyl>methylene-2,2-dimethyl-1,3-dioxane-4,6-dione
(S)-N-carboxylic acid ethyl ester-1-phenyl-1,2,3,4-tetrahydroisoquinoline
(1S)-3,4-dihydro-1-phenyl-2-(1H)-isoquinolinecarboxylic acid (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
solifenacin
