DTPA

  • CAS:67-43-6
  • MF:C14H23N3O10
  • Purity:99%
  • Molecular Weight:393.351
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Product Details

  • CAS: 67-43-6
  • MF: C14H23N3O10
  • Appearance: White crystalline powder
  • Chinese Manufacturer Supply DTPA 67-43-6 On Stock with Competitive Price

    • Molecular Formula:C14H23N3O10
    • Molecular Weight:393.351
    • Appearance/Colour:White crystalline powder 
    • Vapor Pressure:4.77E-25mmHg at 25°C 
    • Melting Point:219-220 °C(lit.) 
    • Refractive Index:1.5700 (estimate) 
    • Boiling Point:721.1 °C at 760 mmHg 
    • PKA:pK1:;pK2:2.55(+1);pK3:4.33(+2);pK4:8.60(-3);pK5,10.58 (25°C) 
    • Flash Point:389.9 °C 
    • PSA:196.22000 
    • Density:1.545 g/cm3 
    • LogP:-2.68460 

    Diethylenetriaminepentaacetic acid(Cas 67-43-6) Usage

    Production Methods

    Pentetic acid is a pentaacetic acid triamine formed during the preparation of the amino carboxylic acid and its salt.

    Pharmaceutical Applications

    Pentetic acid is mainly used as a chelating agent in the preparation of imaging and contrast agents for radionuclide and magnetic resonance imaging.It is also used as a carrier excipient for neutron-capture isotopes in, for example, radiotherapy.Pentetic acid–isotope complexes have also been considered as model active substances in scintigraphic imaging studies.Pentetic acid has been used to chelate metal ions to reduce formation of reactive oxygen species during lyophilization.

    Safety Profile

    Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.

    Safety

    Pentetic acid is used in intrathecal and intravenous injection preparations. The pure form of pentetic acid is moderately toxic by the intraperitoneal route. LD50 (mouse, IP): 0.54 g/kg LD50 (mouse, oral): 4.84 g/kg

    storage

    The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.

    Purification Methods

    Crystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.]

    Incompatibilities

    The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.

    Regulatory Status

    Included in the FDA Inactive Ingredients Database (intrathecal and intravenous injections). Included in intravenous and intra-articular injections licensed in the UK.

    General Description

    Visit our Titration Center to learn more.

    InChI:InChI=1/C4H13N3.5C2H4O2/c5-1-3-7-4-2-6;5*1-2(3)4/h7H,1-6H2;5*1H3,(H,3,4)

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    67-43-6 Process route

    formaldehyd
    50-00-0,30525-89-4,61233-19-0

    formaldehyd

    sodium cyanide
    143-33-9,25596-52-5

    sodium cyanide

    3-azapentane-1,5-diamine
    111-40-0,98824-35-2

    3-azapentane-1,5-diamine

    diethylenetriaminopentaacetic acid
    67-43-6,84932-15-0

    diethylenetriaminopentaacetic acid

    Conditions
    Conditions Yield
    With aqueous alkali;
    diethylenetriaminepentaacetic acid, Ga(III)-salt, dianion
    119088-94-7

    diethylenetriaminepentaacetic acid, Ga(III)-salt, dianion

    2-(HO)-5-(SO<sub>3</sub>H)C<sub>6</sub>H<sub>3</sub>CHNC<sub>2</sub>H<sub>4</sub>NHC<sub>2</sub>H<sub>4</sub>NHC<sub>2</sub>H<sub>4</sub>NCHC<sub>6</sub>H<sub>3</sub>-2-(OH)-5-(SO<sub>3</sub>H)
    139701-37-4

    2-(HO)-5-(SO3H)C6H3CHNC2H4NHC2H4NHC2H4NCHC6H3-2-(OH)-5-(SO3H)

    Ga(N(CHC<sub>6</sub>H<sub>3</sub>-2-O-5-SO<sub>3</sub>))CH<sub>2</sub>NHC<sub>2</sub>H<sub>4</sub>NHC<sub>2</sub>H<sub>4</sub>NCH(C<sub>6</sub>H<sub>3</sub>-2-O-5-SO<sub>3</sub>)

    Ga(N(CHC6H3-2-O-5-SO3))CH2NHC2H4NHC2H4NCH(C6H3-2-O-5-SO3)

    diethylenetriaminopentaacetic acid
    67-43-6,84932-15-0

    diethylenetriaminopentaacetic acid

    Conditions
    Conditions Yield
    In water-d2; competition was followed by H-NMR spectroscopy, at 25 ° C;; aq. soln. of known pH evapd. to dryness, residue dissolved in equal amt. of D2O, left until equilibrium was reached (5 weeks);

    67-43-6 Upstream products

    • 50-00-0
      50-00-0

      formaldehyd

    • 143-33-9
      143-33-9

      sodium cyanide

    • 111-40-0
      111-40-0

      3-azapentane-1,5-diamine

    • 119088-94-7
      119088-94-7

      diethylenetriaminepentaacetic acid, Ga(III)-salt, dianion

    67-43-6 Downstream products

    • 23911-26-4
      23911-26-4

      diethylenetriaminepentaacetic dianhydride

    • 1026294-76-7
      1026294-76-7

      ((2-{[2-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-ethyl)-{[2-(1-tritylsulfanyl-1H-imidazol-4-yl)-ethylcarbamoyl]-methyl}-amino)-acetic acid

    • 280563-35-1
      280563-35-1

      {[2-([2-(bis-carboxymethyl-amino)-ethyl]-{[2-(4-sulfamoyl-phenyl)-ethylcarbamoyl]-methyl}-amino)-ethyl]-carboxymethyl-amino}-acetic acid

    Antioxidant BHT 264

    CAS:128-37-0

    Purity:99%

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