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Benzene Sulfonyl Chloride (BSC)

  • CAS:98-09-9
  • MF:C6H5ClO2S
  • Purity:99%
  • Molecular Weight:176.624
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Product Details

  • CAS: 98-09-9
  • MF: C6H5ClO2S
  • Appearance: clear liquid
  • Excellent chemical plant bulk supply Benzene Sulfonyl Chloride (BSC) 98-09-9

    • Molecular Formula:C6H5ClO2S
    • Molecular Weight:176.624
    • Appearance/Colour:clear liquid 
    • Vapor Pressure:0.04 mm Hg ( 20 °C) 
    • Melting Point:14.5 °C 
    • Refractive Index:n20/D 1.551(lit.)  
    • Boiling Point:251.5 °C at 760 mmHg 
    • Flash Point:105.9 °C 
    • PSA:42.52000 
    • Density:1.4 g/cm3 
    • LogP:2.69490 

    Benzenesulfonyl chloride(Cas 98-09-9) Usage

    Air & Water Reactions

    Insoluble and stable in cold water [Merck]. Decomposes in hot water to produce corrosive and toxic hydrochloric acid and benzenesulfonic acid. Rate of reaction decreases as temperature decreases.

    Reactivity Profile

    Benzenesulfonyl chloride is incompatible with strong oxidizing agents and bases, including amines. Corrodes metals in the presence of water due to slow formation of hydrochloric acid and benzenesulfonic acid [USCG, 1999]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

    Health Hazard

    May be fatal if inhaled, swallowed or absorbed through skin. Contact may cause skin and eye burns. Irritating to eyes, skin and mucous membranes. INGESTION: May cause abdominal spasm and vomiting.

    Safety Profile

    Poison by intraperitoneal route. Adangerous storage hazard. It may explode in a sealedbottle. Explosive reaction with dimethyl sulfoxide. Reactsvigorously with methyl formamide. When heated todecomposition it emits toxic fumes of Cl- and SO

    Potential Exposure

    It is used as a chemical intermediate for benzenesulfonamides, thiophenol, glybuzole (hypoglycemic agent), N-2-chloroehtylamides, benzonitrile; for its esters-useful as insecticides, and miticides.

    Shipping

    UN2225 Benzene sulfonyl chloride, Hazard class: 8; Labels: 8—Corrosive material.

    Purification Methods

    Distil the sulfonyl chloride, then treat it with 3mole % each of toluene and AlCl3, and allow it to stand overnight. The sulfonyl chloride is distilled off at 1mm pressure and then carefully fractionally distilled at 10mm in an all-glass column. [Adams & Marvel Org Synth Coll Vol I 84 1941, Jensen & Brown J Am Chem Soc 80 4042 1958, Beilstein 11 IV 49.] It is TOXIC.

    Incompatibilities

    Violent reaction with strong oxidizers, dimethyl sulfoxide, and methyl formamide. It is very reactive with bases and many organic compounds. Incompatible with ammonia, aliphatic amines. Water contact forms hydrochloric and chlorosulfonic acids. Aqueous solutions of this chemical are strong acids that react violently with bases. Attacks metals in presence of moisture.

    General Description

    A colorless to slightly yellow solid that melts at approximately 40°F. Very irritating to skin, eyes and mucous membranes. May emit toxic fumes when heated to high temperatures. Used to make dyes and other chemicals.

    InChI:InChI=1/C6H5ClO2S/c7-10(8,9)6-4-2-1-3-5-6/h1-5H

    98-09-9 Relevant articles

    -

    Wittmann et al.

    , p. 734 (1969)

    -

    On the reactivity of (7-oxabicyclo[2.2.1]hept-5-en-2-ylidene)amines. Different reaction paths leading to the same final products

    Arjona, Odon,Csaky, Aurelio G.,Murcia, M. Carmen,Plumet, Joaquin

    , p. 3667 - 3672 (2001)

    The reaction of amines, N-substituted by...

    Chromoselective Synthesis of Sulfonyl Chlorides and Sulfonamides with Potassium Poly(heptazine imide) Photocatalyst

    Antonietti, Markus,Guldi, Dirk M.,Markushyna, Yevheniia,Savateev, Aleksandr,Schü?lbauer, Christoph M.,Ullrich, Tobias

    supporting information, p. 20543 - 20550 (2021/08/12)

    Among external stimuli used to promote a...

    Copper-Catalyzed N-Directed Distal C(sp3)-H Sulfonylation and Thiolation with Sulfinate Salts

    Chen, Guang-Le,He, Shi-Hui,Cheng, Liang,Liu, Feng

    supporting information, p. 8338 - 8342 (2021/10/25)

    We herein report a selective and catalyt...

    Facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides

    Chen, Rongxiang,Xu, Shaohong,Shen, Fumin,Xu, Canran,Wang, Kaikai,Wang, Zhanyong,Liu, Lantao

    , (2021/09/20)

    A simple and rapid method for efficient ...

    Proline-Based Allosteric Inhibitors of Zika and Dengue Virus NS2B/NS3 Proteases

    Millies, Benedikt,Von Hammerstein, Franziska,Gellert, Andrea,Hammerschmidt, Stefan,Barthels, Fabian,G?ppel, Ulrike,Immerheiser, Melissa,Elgner, Fabian,Jung, Nathalie,Basic, Michael,Kersten, Christian,Kiefer, Werner,Bodem, Jochen,Hildt, Eberhard,Windbergs, Maike,Hellmich, Ute A.,Schirmeister, Tanja

    , p. 11359 - 11382 (2019/12/24)

    The NS2B/NS3 serine proteases of the Zik...

    98-09-9 Process route

    <i>N</i>,<i>N</i>-dimethyl-aniline
    121-69-7,77733-26-7

    N,N-dimethyl-aniline

    N,N,N',N'-tetramethylbenzidine
    366-29-0

    N,N,N',N'-tetramethylbenzidine

    4-fluoro-N,N-dimethylaniline
    403-46-3

    4-fluoro-N,N-dimethylaniline

    2-fluoro-N,N-dimethylaniline
    393-56-6

    2-fluoro-N,N-dimethylaniline

    1-chloro-2-(dimethylamino)benzene
    698-01-1

    1-chloro-2-(dimethylamino)benzene

    4-(methylamino)benzaldehyde
    556-21-8

    4-(methylamino)benzaldehyde

    4,4'-methylene-bis(N,N-dimethylaniline)
    101-61-1

    4,4'-methylene-bis(N,N-dimethylaniline)

    4-dimethylamino-benzaldehyde
    100-10-7

    4-dimethylamino-benzaldehyde

    benzenesulfonyl chloride
    98-09-9

    benzenesulfonyl chloride

    Conditions
    Conditions Yield
    With zirconium(IV) chloride; N-fluorobis(benzenesulfon)imide; In chloroform; for 5h; Reflux;
    6%
    N-chloro-succinimide
    128-09-6

    N-chloro-succinimide

    ethanol
    64-17-5

    ethanol

    Benzyl phenyl sulfide
    831-91-4

    Benzyl phenyl sulfide

    Succinimide
    123-56-8,89963-74-6

    Succinimide

    ethyl benzenesulfinate
    1859-03-6

    ethyl benzenesulfinate

    benzyl chloride
    100-44-7

    benzyl chloride

    benzenesulfonyl chloride
    98-09-9

    benzenesulfonyl chloride

    Conditions
    Conditions Yield
    In dichloromethane; for 18h; Product distribution; Ambient temperature;
    30%

    98-09-9 Upstream products

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      diphenyl sulphone

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      N,N-dimethylbenzenesulfonamide

    98-09-9 Downstream products

    • 16670-48-7
      16670-48-7

      2-chloroethyl benzenesulfonate

    • 10302-15-5
      10302-15-5

      N-(phenylsulfonyl)aziridine

    • 6453-86-7
      6453-86-7

      N-(2-chloro-ethyl)-benzenesulfonamide

    • 148287-32-5
      148287-32-5

      N-(2-chloro-ethyl)-N-methyl-benzenesulfonamide

    Antioxidant BHT 264

    CAS:128-37-0

    Purity:99%

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