What is the 2-Methylbenzene-1-sulfonamide?

2-Methylbenzene-1-sulfonamide is white to light yellow crystal powder, while it's Molecular Formula is C7H9NO2S. white to light yellow crystal powder o-Toluenesulfonamide is a methylated sulfonamide and a major impurity if Saccharin (S080800). Studies suggest that o-Toluenesulfonamide has potential mutagenic activity.

What is the CAS number for 2-Methylbenzene-1-sulfonamide?

The CAS number of 2-Methylbenzene-1-sulfonamide is 88-19-7.

What is 2-Methylbenzene-1-sulfonamide (88-19-7) used for?

2-Methylbenzene-1-sulfonamide, also known as o-Toluenesulfonamide, is a methylated sulfonamide that appears as colorless crystals. It is soluble in alcohol, slightly soluble in water and ether, and is combustible. It is a major impurity in artificial sweetening substances containing saccharin and has potential mutagenic activity.InChI:InChI=1/C7H9NO2S/c1-6-4-2-3-5-7(6)11(8,9)10/h2-5H,1H3,(H2,8,9,10)

What is the 2-Methylbenzene-1-sulfonamide?

2-Methylbenzene-1-sulfonamide is white to light yellow crystal powder, while it's Molecular Formula is C7H9NO2S. white to light yellow crystal powder o-Toluenesulfonamide is a methylated sulfonamide and a major impurity if Saccharin (S080800). Studies suggest that o-Toluenesulfonamide has potential mutagenic activity.

What is the CAS number for 2-Methylbenzene-1-sulfonamide?

The CAS number of 2-Methylbenzene-1-sulfonamide is 88-19-7.

What is 2-Methylbenzene-1-sulfonamide (88-19-7) used for?

2-Methylbenzene-1-sulfonamide, also known as o-Toluenesulfonamide, is a methylated sulfonamide that appears as colorless crystals. It is soluble in alcohol, slightly soluble in water and ether, and is combustible. It is a major impurity in artificial sweetening substances containing saccharin and has potential mutagenic activity.InChI:InChI=1/C7H9NO2S/c1-6-4-2-3-5-7(6)11(8,9)10/h2-5H,1H3,(H2,8,9,10)

o-Toluene Sulfonamide (OTSA),

CAS：88-19-7
MF：C₇H₉NO₂S
Purity：99%
Molecular Weight：171.22

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Product Details

CAS： 88-19-7

MF： C₇H₉NO₂S

Appearance： white to light yellow crystal powder

High Quality Chinese Factory supply 88-19-7 o-Toluene Sulfonamide (OTSA),

Molecular Formula:C7H9NO2S
Molecular Weight:171.22
Appearance/Colour:white to light yellow crystal powder
Vapor Pressure:0-0.008Pa at 25℃
Melting Point:155 °C
Refractive Index:1.6100 (estimate)
Boiling Point:330.2 °C at 760 mmHg
PKA:10.17±0.60(Predicted)
Flash Point:153.5 °C
PSA：68.54000
Density:1.271 g/cm³
LogP:2.42350

2-Methylbenzene-1-sulfonamide(Cas 88-19-7) Usage

Safety Profile	Suspected carcinogen with experimental tumorigenic data. Mildly toxic by ingestion. Experimental reproductive effects. Mutation data reported. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx. Used as a chemical intermediate in the production of saccharin.
Purification Methods	Crystallise the amide from hot H2O (m 153o), then from EtOH or Et2O/pet ether. The N-o-toluenesulfonylphthalimide has m 182o (from EtOH). [Evans & Dehn J Am Chem Soc 51 3652 1929, Beilstein 11 H 86, 11 I 23, 11 II 39, 11 III 167, 11 IV 229.]
General Description	Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. o-Toluenesulfonamide is a major impurity in artificial sweetening substances containing saccharin.

InChI:InChI=1/C7H9NO2S/c1-6-4-2-3-5-7(6)11(8,9)10/h2-5H,1H3,(H2,8,9,10)

88-19-7 Relevant articles

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Sulfonamide compound and synthesis method and application thereof

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Paragraph 0094-0097, (2019/04/02)

The invention discloses a synthesis meth...

88-19-7 Process route

: 2-methyl-2-(toluene-2-ylsulfonylamino)propionic acid

: 88-19-7
methyl 2-(aminosulfonyl)benzoate

Conditions

Conditions	Yield
With oxygen; copper(II) oxide; In dimethyl sulfoxide; at 100 ℃; for 8h;	93%

: 2093-46-1
2-methylphenyl diazonium tetrafluoroborate

: 88-19-7
methyl 2-(aminosulfonyl)benzoate

Conditions

Conditions	Yield
With sodium metabisulfite; sodium azide; tetrabutylammomium bromide; triphenylphosphine; In water; acetonitrile; at 80 ℃; for 12h; Inert atmosphere;	70%
With sodium metabisulfite; sodium azide; tetrabutylammomium bromide; triphenylphosphine; In water; acetonitrile; at 80 ℃; for 12h; Inert atmosphere; Schlenk technique;	70%