What is the TRICHOSTATIN A?

TRICHOSTATIN A is Off-white powder, while it's Molecular Formula is C 17 H 22 N 2 O 3 . Off-white powder Trichostatin A, ready-made solution has been used:as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testingto inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)to treat cells for the HDAC inhibition experiments

What is the CAS number for TRICHOSTATIN A?

The CAS number of TRICHOSTATIN A is 58880-19-6.

What is TRICHOSTATIN A (58880-19-6) used for?

Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo.InChI:InChI=1/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+

What is the TRICHOSTATIN A?

TRICHOSTATIN A is Off-white powder, while it's Molecular Formula is C 17 H 22 N 2 O 3 . Off-white powder Trichostatin A, ready-made solution has been used:as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testingto inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)to treat cells for the HDAC inhibition experiments

What is the CAS number for TRICHOSTATIN A?

The CAS number of TRICHOSTATIN A is 58880-19-6.

What is TRICHOSTATIN A (58880-19-6) used for?

Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of primordial germ cells into embryonic germ cells. Cell permeable and active in vivo.InChI:InChI=1/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+

TRICHOSTATIN A

CAS：58880-19-6
MF：C₁₇H₂₂N₂O₃
Purity：99%
Molecular Weight：302.373

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Product Details

CAS： 58880-19-6

MF： C₁₇H₂₂N₂O₃

Appearance： Off-white powder

Factory supply TRICHOSTATIN A 58880-19-6 with sufficient production capacity

Molecular Formula:C₁₇H₂₂N₂O₃
Molecular Weight:302.373
Appearance/Colour:Off-white powder
Melting Point:141°C -143°C
Refractive Index:136 ° (C=0.3, MeOH)
PKA:8.93±0.23(Predicted)
PSA：69.64000
Density:1.139 g/cm³
LogP:2.97020

TRICHOSTATIN A(Cas 58880-19-6) Usage

Biological Activity	Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.
Biochem/physiol Actions	Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.
General Description	Trichostatin A is a compound of primary hydroxamic acid.

InChI:InChI=1/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+

58880-19-6 Relevant articles

Evolution of concise and flexible synthetic strategies for trichostatic acid and the potent histone deacetylase inhibitor trichostatin A

Cosner, Casey C.,Bhaskara Reddy Iska, Vijaya,Chatterjee, Anamitra,Markiewicz, John T.,Corden, Steven J.,Loefstedt, Joakim,Ankner, Tobias,Richer, Joshua,Hulett, Tyler,Schauer, Douglas J.,Wiest, Olaf,Helquist, Paul

, p. 162 - 172 (2013/02/23)

(R)-(+)-Trichostatic acid and (R)-(+)-tr...

SYNTHESIS OF HDAC INHIBITORS: TRICHOSTATIN A AND ANALOGUES

-

Page/Page column 4, (2011/10/12)

Embodiments herein relate to histone dea...

OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT

-

, (2009/12/28)

An object of the present invention is to...

Processes and compounds for preparing histone deacetylase inhibitors and intermediates thereof

-

Page/Page column title page; 12, (2010/11/25)

Processes for preparing unsaturated este...

58880-19-6 Process route

: 122222-87-1
O-(2-methoxypropyl)-(R)-trichostatin A

: 58880-19-6,122292-85-7
trichostatin A

: 122292-85-7
(S)-(-)-trichostatin A

Conditions

Conditions	Yield
With Amberlyst 15; In methanol; at 45 ℃; for 1h; Yields of byproduct given. Title compound not separated from byproducts;	81%

: 1334686-47-3
C₂₃H₃₆N₂O₃Si

: 58880-19-6,122292-85-7
trichostatin A

Conditions

Conditions	Yield
With methanol; cesium fluoride; at 20 ℃; for 3h;

58880-19-6 Upstream products

122222-87-1
O-(2-methoxypropyl)-(S)-trichostatin A
122222-87-1
O-(2-methoxypropyl)-(R)-trichostatin A
934246-98-7
ethyl (2E,4E)-(6R,7R)-7-[4-(dimethylamino)phenyl]-7-hydroxy-4,6-dimethylhepta-2,4-dienoate
122222-78-0
(S)-3-(4-Dimethylamino-phenyl)-3-(1-methoxy-1-methyl-ethoxy)-2-methyl-propionaldehyde

58880-19-6 Downstream products

1298085-51-4
2,3-dihydrotrichostatin A
68676-88-0
trichostatin C

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