Antioxidant BHT 264
CAS:128-37-0
Purity:99%
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Valsartan is white crystalline powder, while it's Molecular Formula is C24H29N5O3. Valsartan is used as a first-line drug for the treatment of uncomplicated hypertension, isolated systolic hypertension, and left ventricular hypertrophy. Valsartan is a clinically widely used antihypertensive agent with the advantages of low side effects and good tolerability, and can also be used for the treatment of hypertension in patients with diabetes and renal disease.
The CAS number of Valsartan is 137862-53-4.
More information of Valsartan 137862-53-4 are:
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Synonyms |
L-Valine,N-(1-oxopentyl)-N-[[2'-(1H-tetrazol- 5-yl)[1,1'-biphenyl]-4-yl]methyl]-;Diovan;Diovan (TN);L-Valine, N-(1-oxopentyl)-N-((2-(1H-tetrazol-5-yl)(1,1-biphenyl)-4-yl)methyl)-;N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine;Valsartan [USAN:INN];N-(1-n.Pentanoyl)-N-[[2'-(1H-tetrazol-5-yl)[1',1- biphenyl]-4-yl]methyl]-L-valine;Dihydrotachystero;Valsartan USP30; |
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CAS Number |
137862-53-4 |
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Molecular Formula |
C24H29N5O3 |
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Molecular Weight |
435.526 |
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Density |
1.212 g/cm3 |
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Melting Point |
116-117 °C |
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Boiling Point |
684.9 °C at 760 mmHg |
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Flash Point |
368 °C |
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HS CODE |
29339900 |
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PSA |
112.07000 |
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LogP |
4.16170 |
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Pka |
3.56±0.10(Predicted) |
Diovan(Valsartan) was launched in Germany and the UK as an angiotensin Ⅱ antagonist for use as an antihypertensive agent. Biphenylbromomethyl nitrite serves as the starting material for a three step synthesis of the compound, in which the (S)- enantiomer is more active than the (R)-enantiomer. Valsartan is a nonpeptide drug which is a highly specific antagonist of the AT1 receptor and is potent and orally active. This receptor is responsible for angiotensin Ⅱ cardiovascular effects (aldosterone and catecholamine secretion, vascular constriction, positive inotropic response and renal effects). Unlike losartan, it is not a prodrug and a single daily dose is comparible in activity to the ACE drug enalapril. It also did not exhibit the coughing side effect observed with ACE inhibitors. Diovan(Valsartan) is slowly metabolized (long lasting) with its main metabolite being significantly less active. There was no evidence of rebound hypertension when drug treatment was terminated and was as effective as the dihydropyridine Ca antagonist anlodipine.
InChI:InChI=1/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m1/s1
Articles related to Valsartan:
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Article |
Source |
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tris(2-Perfluorohexylethyl)tin azide: A new reagent for preparation of 5-substituted tetrazoles from nitriles with purification by fluorous/organic liquid-liquid extraction |
Curran, Dennis P.,Hadida, Sabine,Kim, Sun-Young , p. 8997 - 9006 (1999) |
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Preparation of Tetrazoles from Organic Nitriles and Sodium Azide in Micellar Media |
Jursic, Branko S.,LeBlanc, Blaise W. , p. 405 - 408 (1998) |
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