Antioxidant BHT 264
CAS:128-37-0
Purity:99%
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Product Details
|
General Description |
2-(diphenylmethyl)-quinuclidin-3-one is a chemical compound with the molecular formula C28H29NO. It is a quinuclidine derivative that acts as a potent and selective negative allosteric modulator of the muscarinic acetylcholine M1 receptor. 2-(DIPHENYLMETHYL)-QUINUCLIDIN-3-ONE has been studied for its potential therapeutic applications, particularly in the treatment of conditions such as Alzheimer's disease and schizophrenia, where modulation of the M1 receptor has shown promise. Research has also focused on its potential role in cognitive enhancement and improving memory function. As a negative allosteric modulator, it blocks the binding of acetylcholine to the M1 receptor, thereby altering its activity and potentially leading to beneficial effects in specific brain functions. |
InChI:InChI=1/C20H21NO/c22-20-17-11-13-21(14-12-17)19(20)18(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-10,17-19H,11-14H2
A method for the enantioselective synthe...
The present invention discloses a proces...
The invention discloses a method of synt...
The present invention relates to a prepa...
![(Z)-2-benzylidene-1-azabicyclo[2.2.2]octan-3-one](/upload/2025/4/3c6dfa22-2d76-4e68-9f32-5ff625f1249a.png)
(Z)-2-benzylidene-1-azabicyclo[2.2.2]octan-3-one
phenylmagnesium chloride
3-keto-2-benzhydrylquinuclidine
| Conditions | Yield |
|---|---|
|
With
copper(I) bromide;
In
tetrahydrofuran;
at -5 - 25 ℃;
Reagent/catalyst;
Temperature;
|
85% |
|
With
copper(l) iodide;
In
tetrahydrofuran; benzene;
at 0 - 20 ℃;
Inert atmosphere;
|
0.3% |
(Z)-2-benzylidene-1-azabicyclo[2.2.2]octan-3-one
phenylmagnesium bromide
3-keto-2-benzhydrylquinuclidine
| Conditions | Yield |
|---|---|
|
phenylmagnesium bromide;
With
copper(I) bromide dimethylsulfide complex;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
Inert atmosphere;
Large scale;
(Z)-2-benzylidene-1-azabicyclo[2.2.2]octan-3-one;
In
tetrahydrofuran;
at 5 - 10 ℃;
for 3h;
Large scale;
|
75% |
(Z)-2-benzylidene-1-azabicyclo[2.2.2]octan-3-one
phenylmagnesium chloride
3-Quinuclidinone
benzaldehyde
cis-2-(diphenylmethyl)-N-(phenylmethyl)-1-azabicyclo<2.2.2>octan-3-amine
(2-benzhydryl-1-aza-bicyclo[2.2.2]oct-3-ylidene)-benzyl-amine
(-)-(2R,3S)-2-(diphenylmethyl)-1-azabicyclo<2.2.2>octan-3-ol
(-)-cis-2-(diphenylmethyl)-1-azabicyclo<2.2.2>octan-3-amine
