Antioxidant BHT 264
CAS:128-37-0
Purity:99%
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Product Details
|
Brand name |
Tequin |
InChI:InChI=1/C19H22FN3O4.ClH/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26;/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26);1H
The invention relates to a gatifloxacin ...
Methods of synthesizing fluoroquinolones...
The present invention relates to a metho...
An improved process to obtain gatifloxac...
(RS)-2-methylpiperazine
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
gatifloxacin
| Conditions | Yield |
|---|---|
|
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid;
With
1,1,1,3,3,3-hexamethyl-disilazane;
In
acetonitrile;
at 76 - 80 ℃;
for 1h;
Heating / reflux;
With
boron trifluoride diethyl etherate;
In
acetonitrile;
at 0 - 25 ℃;
for 2h;
(RS)-2-methylpiperazine;
With
triethylamine;
In
acetonitrile;
at 15 - 25 ℃;
for 3h;
pH=~ 9;
|
81.8% |
|
In
dimethyl sulfoxide;
at 55 ℃;
for 24h;
|
66% |
|
In
dimethyl sulfoxide;
at 60 - 65 ℃;
for 29 - 45h;
|
53.7% |
|
In
dimethyl sulfoxide;
at 20 - 73 ℃;
for 13.9167 - 14.3333h;
|
52% |
|
In
dimethyl sulfoxide;
at 70 - 95 ℃;
for 2h;
|
1-cyclopropyl-7-(3-methylpiperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid boron difluoride chelate
gatifloxacin
| Conditions | Yield |
|---|---|
|
With
water;
In
ethanol;
at 70 - 80 ℃;
for 2h;
|
91.7% |
|
With
methanol;
at 63 - 67 ℃;
for 5h;
|
(RS)-2-methylpiperazine
1-cyclopropyl-1,4-dihydro-6,7-difluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid difluoroborate ester
1-cyclopropyl-7-(3-methylpiperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid boron difluoride chelate
1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
(+/-)-1-cyclopropyl-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-8-methoxy-4-oxo-3-quinoline carboxylic acid sesquihydrate
(+/-)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methylpiperazinyl)-4-oxo-3-quinolinecarboxylic acid hemiihydrate
(+/-)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methylpiperazinyl)-4-oxo-3-quinolinecarboxylic acid dihydrate
(+/-)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methylpiperazinyl)-4-oxo-3-quinolinecarboxylic acid hemihydrate
