Antioxidant BHT 264
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High Quality Chinese Manufacturer supply 70458-96-7 Norfloxacin We supply high quality Norfloxacin (CAS 70458-96-7), in stock, factory directly supply to clients, lower prices, more competitiveness.
Norfloxacin is Off-white to light yellow cryst powder, while it's Molecular Formula is C16H18FN3O3. Pefloxacin derivative as antibacterial. Fluorinated quinolone antibacterial.
The CAS number of Norfloxacin is 70458-96-7.
More information of Norfloxacin 70458-96-7 are:
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Synonyms |
1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinolinecarboxylicacid;AM 715;Amicrobin;Baccidal;Barazan;Barotham;Chibroxin;Chibroxine;Esclebin;Floxacin;Floxacin 400;Fulgram;Gonorcin;Lexinor;Mk 0366;N-Demethylpefloxacin;N-Desmethylpefloxacin;Neofloxacin;Neofloxin;Noflo;Nofocin;Nolicin;Noracin;Noraxin;Norbid;Norflox 400; |
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CAS Number |
70458-96-7 |
|
Molecular Formula |
C16H18FN3O3 |
|
Molecular Weight |
319.336 |
|
Density |
1.344 g/cm3 |
|
Melting Point |
220 °C |
|
Boiling Point |
555.8 °C at 760 mmHg |
|
Flash Point |
289.9 °C |
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HS CODE |
29335990 |
|
PSA |
74.57000 |
|
LogP |
1.66210 |
|
Pka |
pKa1 6.34; pKa2 8.75(at 25℃) |
Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 μg/ml for S. aureus and P. aeruginosa, respectively). It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC50s = 0.25, 1, 0.03, 1, and 1 μg/ml, respectively). Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day. Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.
InChI:InChI=1/C16H18FN3O3.C3H6O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20;1-2(4)3(5)6/h7-9,18H,2-6H2,1H3,(H,22,23);2,4H,1H3,(H,5,6)
Articles related to Norfloxacin:
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Article |
Source |
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Studies on Prodrugs. 10. Possible Mechanism of N-Dealkylation of N-Masked Norfloxacins Having Several Active Methylene Groups |
Kondo, Hirosato,Sakamoto, Fumio,Inoue, Yoshimasa,Tsukamoto, Goro , p. 679 - 682 (1989) |
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A norfloxacin, ciprofloxacin and enrofloxacin synthetic method |
- Paragraph 0006; 0016-0027; 0040; 0041, (2019/07/10) |
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