Antioxidant BHT 264
CAS:128-37-0
Purity:99%
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Cushing’s disease is defined as hypercortisolism due to chronic overproduction of corticotrophin by a corticotroph adenoma. Cortisol’s lack of suppressibility during the administration of low doses of dexamethasone but suppressibility during high-dose dexamethasone is the key diagnostic finding in 99% of the patients with Cushing’s disease. This contrasts with the lack of glucocorticoid suppressibility typically found in patients with corticotrophin-independent hypercortisolism (Cushing’s syndrome). A judicious selection of the available tests may be necessary to obtain an accurate diagnosis in patients with Cushing’s syndrome.
Anti-inflammatory glucocorticoidDexamethasone is used to treat inflammatory and autoimmune conditions such as rheumatoid arthritis and bronchospasm. It is useful to study apoptosis, cell signaling pathways and gene expression. It is associated with marbofloxacin and clotrimazole and finds application in veterinary medicine to treat difficult ear infections in dogs. It is also used to treat horses with swelling of of distal limbs and general bruising in combination with trichlormethiazide. It is also an anti-inflammatory glucocorticoid.
C23H31FO4
dexamethasone
| Conditions | Yield |
|---|---|
|
C23H31FO4;
In
ethyl acetate;
at 0 - 10 ℃;
With
hydrogenchloride;
In
water;
at 30 - 35 ℃;
for 1h;
|
40% |
betamethasone
dexamethasone
| Conditions | Yield |
|---|---|
|
In
ethanol;
at 24 - 26 ℃;
for 96h;
Penicillium decumbens ATCC 10436, potato dextrose broth;
|
5% |
|
With
methanol; sodium carbonate;
at 20 ℃;
for 0.166667h;
Temperature;
|
The CAS number of Dexamethasone is 50-02-2.
More information of Dexamethasone 50-02-2 are:
|
CAS Number |
50-02-2 |
|
Density |
1.32 g/cm3 |
|
Melting Point |
262-264 °C(lit.) |
|
Boiling Point |
568.2 °C at 760 mmHg |
|
Flash Point |
297.5 °C |
|
Vapor Pressure |
2.81E-15mmHg at 25°C |
|
Refractive Index |
76 ° (C=1, Dioxane) |
|
HS CODE |
HASONE DISODIUM PHOSPHATE PRODUCT IDENTIFICATION |
|
PSA |
94.83000 |
|
LogP |
1.89570 |
|
Pka |
12.13±0.70(Predicted) |
Synonyms for Dexamethasone 50-02-2:Diodex;Etacortilen;Fluormone;Fluorocort;Gammacorten;HL-Dex;Hexadecadrol;Hexadrol;Isopto-Dex;Loverine;Luxazone;Millicorten;Oradexon;Pet-Derm III;Prednisolone F;Superprednol;Surodex;Visumetazone;Pregna-1,4-diene-3,20-dione,9-fluoro-11,17,21-trihydroxy-16-methyl-, (11b,16a)-;Pregna-1,4-diene-3,20-dione,9-fluoro-11b,17,21-trihydroxy-16a-methyl- (6CI,8CI);1-Dehydro-16a-methyl-9a-fluorohydrocortisone;16a-Methyl-9a-fluoro-D1-hydrocortisone;16a-Methyl-9a-fluoroprednisolone;9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione;9a-Fluoro-16a-methyl-1,4-pregnadiene-11b,17a,21-triol-3,20-dione;9a-Fluoro-16a-methyl-11b,17,21-trihydroxypregna-1,4-diene-3,20-dione;9a-Fluoro-16a-methylprednisolone;Adexone;Aeroseb-Dex;Aphtasolon;Aphthasolone;Azium;Calonat;Corsone;Decacort;Decaderm;Decadron;Decadron A;Dekort;Delipos;Dergramin;Desameton;Dexa-Cortidelt;Dexa-Scheroson;Dexacortin;Dexalona;Dexamethasone alcohol;Dexapolcort;Dexaprol;Dexason;Dexinoral;Dexmethsone;Dexonium;Dinormon;
The chemical formula of Dexamethasone is C22H29FO5 which containing 22 Carbon atoms,29 Hydrogen atoms,1 Fluorine atoms and 5 Oxygen atoms,and the molecular weight of Dexamethasone is 392.468.
The activity of dexamethasone, as measured by glycogen deposition, is 20 times greater than that of hydrocortisone. It has five times the anti-inflammatory activity of prednisolone. Clinical data indicate that this compound has seven times the antirheumatic potency of prednisolone. It is roughly 30 times more potent than hydrocortisone. Its pharmacokinetics are presented in Table 33.3. Routes of metabolism for dexamethasone are similar to those for prednisolone, with its primary 6β-hydroxy metabolite being recovered in urine. Dexamethasone sodium phosphate is the water-soluble sodium salt of the 21-phosphate ester, with an IV half-life of less than 10 minutes because of rapid hydrolysis by plasma phosphatases. Peak plasma levels for dexamethasone usually are attained in approximately 10 to 20 minutes following its IV administered dose. A similar reaction occurs when the phosphate ester is applied topically or by inhalation.
InChI:InChI=1/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15?,16+,17+,19+,20+,21+,22+/m1/s1
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|
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- , (2020/03/12) |
|
A 17, 21 - double-hydroxy steroid derivatives of synthetic method |
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